Gliptins or dipeptidyl peptidase-4 inhibitors are used to lower blood sugar levels to treat diabetes type 2. They work by increasing insulin and suppressing glucagon. These drugs include:

• Alogliptin (Nesina)
• Alogliptin-metformin (Kazano)
• Alogliptin-pioglitazone (Oseni)
• Llinagliptin (Tradjenta)
• Llinagliptin-empagliflozin (Glyxambi)
• Llinagliptin-metformin (Jentadueto)
• Saxagliptin (Onglyza)
• Saxagliptin-metformin (Kombiglyze XR)
• Sitagliptin (Januvia)
• Sitagliptin-metformin (Janumet and Janumet XR)
• Sitagliptin and simvastatin (Juvisync)

Are You Putting Your Heart At Risk While Treating Diabetes With Onglyza?
https://www.forthepeople.com/blog/are-you-putting-your-heart-at-risk-while-treating-diabetes-with-onglyza/

FDA: 2 Diabetes Drugs May Be Linked to Heart Failure Risk
https://health.usnews.com/health-news/articles/2016-04-05/fda-2-diabetes-drugs-may-be-linked-to-heart-failure-risk

Gliptin Treatment Tied to Higher Risk of Acute Pancreatitis
Data were included from SAVOR-TIMI 53 (saxagliptin), EXAMINE (alogliptin), and TECOS (sitagliptin).
Source [Not Secure] m-dot-physiciansbriefing-dot-com/article.htm?CID=0B3F45B2&NFID=P&articleId=715193

Classes of Medications

• Alpha-glucosidase inhibitors
• Biguanides (metformin)
• Dopamine agonist (Cycloset)
• DPP-4 inhibitors (gliptins) (Januvia, Onglyza)
• GLP-1 (glucagon-like peptides) (Trulicity, Victoza)
• Insulin
• Meglitinides
• Sodium glucose transporter (SGLT-2 Inhibitors) (Farxiga, Invokana, Jardiance)
• Sulfonylureas (glipizide, glyburide)
• Thiazolidinediones (Avandia, Actos)